Licensing Example: For-Profit Use of LifeAct in Internal Research
Actin is the most abundant protein in most eukaryotic cells, and is involved in many crucial processes, such as cell division, endocytosis, cell migration, and chemotaxis.
Using LifeAct, a novel marker for the visualization of F-actin in living cells, enables your team to do live imaging of the cytoskeletal organization and cellular dynamics.
Actin functionality is not only crucial in cardiovascular diseases, but data are also showing the importance in oncology, neurobiology, and nephrology. When using LifeAct, angiogenesis processes and endothelial cell biology are specifically addressed.
Original publication: Riedl J, et al. (2008) Lifeact: a versatile marker to visualize F-actin. Nat Methods 5(7):605–607. read abstract
F-actin visualization in primary myocytes expressing LifeAct-TagGFP2-mRNA.
LifeAct: Facts and Benefits
Visualizes F-actin in living and fixed eukaryotic cells with excellent signal-to-noise ratio
Specifically binds F-actin and is coupled to the fluorescence marker GFP or RFP