• ibiBoost<sup>TM</sup> Adeno Adenovirus Transduction Enhancer
  • ibiBoost<sup>TM</sup> Adeno Adenovirus Transduction Enhancer

ibiBoostTM Adeno Adenovirus Transduction Enhancer

A support reagent for enhancing the efficiency of viral gene transfer into difficult-to-transduce mammalian and rodent cells

  • Efficient, due to 20- to 50-fold enhanced adenovirus transduction
  • A non-toxic, peptide-based solution
  • Gives access to nearly all cell types

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Cat. No. Description Pcs./Box
50301 ibiBoost Adeno Adenovirus Transduction Enhancer Solution, 50 transductions 1

Applications:

  • Adenovirus transduction


NOTE:

Please note that you will be working with samples containing an infectious virus. Follow the recommended NIH guidelines for all materials containing BSL–2 organisms.


Technical Features:

  • Gives access to cells that express little CAR (Coxsackie Adenovirus Receptor)


ibiBoost Adenovirus Transduction Enhancer has been specifically developed to improve the uptake of adenovirus vectors (e.g., rAV-LifeAct Adenoviral Vectors) into cells and cell lines that are normally difficult to transduce. ibiBoost reagent is unique, because it is based on an adenovirus binding peptide. Due to this factor, ibiBoost changes the adenovirus surface in a way that the uptake of the adenovirus is improved for all permissive cell types, and it allows transduction of cell types previously not accessible to adenovirus transduction. Unlike chemical transduction enhancers, ibiBoost has no toxic effects. The use of ibiBoost is especially recommended if high ”Multiplicities of Infection“ (MOI), exceeding 500, have to be applied to a particular cell type.

 

Specifications:

Volume 125 μl
Amount For 50 transductions à 1 × 107 IU
Storage 4°C


ibiBoost™ Adeno Adenovirus Transduction
Enhancer significantly enhanced GFP
expression in rodent NIH-3T3 cells

Enhancing Transduction Efficiency

I: Genetic manipulation of target cells increases the CAR expression on the cell surface.

II: Genetic manipulation of the adenovirus binding domain addresses the  non-CAR surface receptors of the target cell.

III: The ibiBoost Adeno Adenovirus Transduction Enhancer bridges the adenovirus surface to the cell membrane, thereby enhancing the gene expression by 20- to 50-fold into cell types that lack the primary adenovirus receptor CAR. 


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